AUC prediction equations of tacrolimus with 2–5 sample points show high performance
898)
Model-independent pharmacokinetic parameters for tacrolimus were calculated and dose-corrected when appropriate: AUC 12, peak plasma concentration (C
We evaluated
5–2 ng/mL), the two most widely used assays for the drug use blood samples
, in 2014 using C 0-C 1-C 4 and C 0-C 2-C 4 values observed in our cohort, yielded 225 ± 52 (range: min 127- max 345) and 223 ± 51 (range: min 129- max 329) ng*h/mL, respectively
592 × C 3 + 1
783 × C 4 In total, 63 paired tacrolimus AUC 0–24 and 43 paired mycophenolic acid AUC 0–12 values and concurrent dosing recommendations were included in the AUC analysis
9 (C 2: 2-h postdose tacrolimus level; C 4: 4-h postdose tacrolimus level)
Tacrolimus has a narrow therapeutic range and requires dose adjustment, usually based on the trough blood concentration but preferably on the area under the concentration–time curve over 12 h post-dose (AUC 0–12h)
204
bolus administration: k t k nk e e e e e e V D Cn t 1 1 ( ) In the outpatient department, a LSS using C(0h)-C(2h)-C(4h) can be used for reliable estimation of the AUC(0-24) of prolonged-release tacrolimus
Similar to cyclosporine
Our randomized trial was an open-label single-dose testing with four-periods and two-sequences; we aimed to evaluate the bioequivalence between a generic and branded tacrolimus by establishing their area under concentration-time curve (AUC) predictive equations
8-40
AUC could also be an important target, as this will leave the intra-patient variability out of the equation since you do not know on beforehand if a patient will have relatively high or low concentrations
6%)
97) and also had the better prediction precision and accuracy compared with the other models