This half-life increases in patients with impaired renal function [ 7 ]
Patients with end-stage renal disease or those who required renal replacement therapy during hospitalization were excluded
8 There is currently, no consensus on dose modification of baclofen in patients with renal failure, despite it being renally excreted, and being known to potentiate adverse neurological effects at
5-6
Usual Gabapentin Dosing (Adults) Usual initial gabapentin dose: 300mg q8h
Manufacturers do not provide specific dosing adjustment recommendations in patients with renal impairment
effect (success, failure, or toxicity), dose adjustments are necessary when renal function is considerably reduced
Dose reduction is required more as the severity of renal impairment increases
Patients with severely impaired renal function generally develop baclofen intoxication soon after the initiation of low-dose therapy
relationship of renal failure with baclofen toxicity
Not
somnolence, lethargy) (see sections 4
The influence of kidney disease on drug prescribing
Screening dose: Initial: 50 mcg for 1 dose; following initial administration, observe patient for 4 to 8 hours
A study in 2011 highly recommended changes in labeling with improved guidelines in dosing
Opioid use should be minimized with careful monitoring and dose adjustment
The daily dose of baclofen ranged from 5 to 60 mg with a mean dose of 20 mg
Although baclofen is dialyzable in cases of toxicity, it should be avoided in patients with end-stage renal disease requiring hemodialysis