It is also associated with other medicines, including ciclosporin and some anticonvulsants 2,3
reported gingival hypertrophy in patients receiving 10 mg of amlodipine daily within two months of the onset of
There are only certain case reports of amlodipine-induced gum hyperplasia
amlodipine (Norvasc) ethosuximide (Zarontin lamotrigine (Lamictal) nifedipine (Adalat) phenobarbitone (Luminal) primidone (Mysoline) topiramate (Topamax) vigabatrin (Sabril)
Among the first-line medications for hypertension are calcium channel blockers, such as amlodipine
The increased overgrowth of gingival tissue is related to the disruption of the degradation of collagen, which leads to a larger amount of extracellular collagen tissue
Previously, we reported a case of gingival enlargement in a patient with severe hypertension whose gingival enlargement improved after initial periodontal therapy
Epub 2015 Apr 14
reported three cases taking 5–10 mg of amlodipine daily who presented with significant probing depth and exhibited a gingival
Both individuals taking amlodipine alone and in combination with other antihypertensive drugs showed the same level of gingival enlargement
The purpose of this study was to examine a large group of patients taking amlodipine and determine the prevalence of gingival hyperplasia
Although CCB-induced gingival enlargement is a known adverse effect, it is rarely or never caused by some CCBs
Drug-induced gingival hyperplasia was reclassified in 1999 by APP as a dental plaque-induced gingival disease
14 Other case reports have also associated other CCBs with gingival enlargement
Gingival hypertrophy due to drugs is termed as “drug-induced gingival overgrowth (DIGO)”
The inflammation is often caused by plaque buildup on the teeth from food, bacteria, and poor Amlodipine is an oral dihydropyridine calcium channel blocker with structural similarities to nifedipine, which commonly causes gum hypertrophy [ 1 ]
This increase in gingival cells has many different causes, but one of the most common is drug-induced gingival hyperplasia
Gingival hypertrophy causes difficulty in speech and mastication, poor oral
The mean dose
3 Seymour et al 4 were the first to report on amlodipine-induced The first case of nifedipine-induced gingival enlargement was reported in mid 1980s by Lederman et al
Amlodipine-induced gingival overgrowth is generally reported at the dose of 10 mg/day within three months of drug initiation [5,6]
We report, three cases of gingival hyperplasia induced by amlodipine, a second generation calcium channel blocker
Asima N
Angioedema; depression; erectile dysfunction; gingival hyperplasia; myalgia More than 20 drugs are associated with gingival overgrowth