Our results reveal previously unrecognized high-dimensional structure within the phenotypic landscape of cluster headache that enables prediction of treatment response with modest fidelity Verapamil is a medication sometimes prescribed to prevent migraine headaches
Neuromodulation is becoming an increasingly popular option, both non-invasively such as vagus Cluster Headaches
The mechanism of verapamil in CH is unclear, like steroids it has multiple potential mechanisms
The TACs include cluster headache, paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks, and hemicrania continua
The mechanism of action in CH is still subject to speculation
1, 2 Compounding the morbidity of the disease, there can be a significant delay in diagnosis of up to eight
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Verapamil is considered the first-line agent for cluster headache prophylaxis
Verapamil has been used in the prevention of CH for almost 3 decades, however, the mode of action and therapeutic target is still unknown
Prophylactic treatment with verapamil and lithium currently has the highest level of evidence for efficacy
The disabling nature of migraine headaches leads to frequent visits to outpatient clinics and emergency department facilities, causing significant health and financial burdens
After 5 days’ run-in, 15 patients received verapamil (120 mg tid) and 15 received placebo (tid) for 14 days