A study reported that only 10% of elderly hypertensive women with diuretic-associated hyponatremia received a low dose of hydrochlorothiazide (12
In brief
1 found that 3 in 10 patients exposed to thiazides develop hyponatremia and that the risk of developing hyponatremia was 60% higher in patients treated with thiazide than in those
Hyponatraemia (defined as serum sodium <135 mmol/L) is the most common electrolyte abnormality and is encountered in all areas of clinical practice
CONCLUSIONS: This is a case of an elderly female on SSRI and hydrochlorothiazide presenting with serum sodium of 93 mEq/L
Hyponatremia thiazide diuretic osmotic demyelination hypertonic saline antidiuretic hormone (ADH) hydrochlorothiazide chlorthalidone indapamide metolazone
6%21)
The primary aim of the study was reducing serum sodium concentration (sNa) in
Although there is a wide variation in the timing of presentation of drug-induced hyponatremia, (equivalent to 12
INTRODUCTION: Severe hyponatremia, defined as serum sodium <120 mEq/L, is a life-threatening condition that can result in neurological complications including seizure and death
He received a diagnosis of hyponatremia, which could potentially account for his Hydrochlorothiazide and Chlorthalidone Induced Hyponatremia – A Comparative Analysis for Concern
Also, many and sometimes complex factors influence the serum sodiumconcentration
ADH exerts its effects on the distal convoluted tubule and collecting duct of the nephron by upregulating aquaporin-2 channels (AQP2) on the cellular apical membrane surface
It is the most common electrolyte imbalance detected among all medical fields
Hyponatremia was classified as moderate if the serum sodium was 125 mmol/L to 130 mmol/L, severe if it was 120 mmol/L to 124 mmol/L, and very severe if <120 mmol/L
This is associated with insufficient arginine vasopressin (AVP)
RESULTS
Atenolol 25 mg daily by mouth was added to the patient’s regimen of HCTZ 25 mg daily
Hydrochlorothiazide Muhammad Jabar Rashid 1
1 In December 2006, losartan potassium/hydrochlorothiazide was introduced into the Japanese market as Preminent® (Banyu Pharmaceutical Co
* hospitalisation
Hydrochlorothiazide is a white, or practically white, crystalline powder, which is slightly soluble in water, but freely soluble in sodium hydroxide solution
This is more common in the elderly patients
The patients in this Severe hyponatremia is a rare, but important, complication of thiazide diuretics