Tamoxifen is the most widely prescribed endocrine therapy for breast cancer, with more
The effect of tamoxifen, an antiestrogenic agent, on lipid metabolism was studied in
Tamoxifen (Nolvadex) is used to prevent and treat estrogen receptor
Laboratory values include: Serum amylase 778 IU/L, total cholesterol 785 mg/dL, triglycerides 4568 mg/dL and high-density lipoproteins (HDL) 12 mg/dL
However, high density lipoprotein cholesterol (HDL-C) and the HDL-C/total-C ratio rose significantly
(A and D) A375 and B16F10 cells were treated with indicated concentration of tamoxifen in- combination with MCD and cholesterol
At 6 months, exemestane appeared to stabilize total cholesterol and HDL cholesterol levels as did tamoxifen (Markopoulos et al, 2003)
Thus, inhibition of the delta 8-isomerase may be the major hypolipidemic effect of these agents
Among them, 360 (3
In fact, for people who have estrogen-receptor-positive tumors, Cholesterol causes a number of important actions within a cell, Riggins says, and there are two potential explanations as to why high levels of cholesterol might be related to tamoxifen resistance However, tamoxifen is a SERM: it is anti-oestrogenic in breast and mammary tissue 52, but acts as an oestrogen-like compound in bone 68 and also lowers circulating cholesterol, whereas it has Methods and results: Oral tamoxifen (TMX) at a dose of 1
Background: Tamoxifen (TAM) is an important cancer therapeutic and an experimental tool for effecting genetic recombination using the inducible Cre-Lox technique
increases cholesterol and triglyceride levels, adds body fat while decreasing muscle and impairs the body's ability to Total cellular cholesterol level was reduced by >25% in the cells treated with tamoxifen and MCD combination as compared to tamoxifen alone (Additional file7: Figure S6)
In total, you could receive up to 10 years of benefit
Over time, the fatty deposits can decrease the amount of blood flowing in the arteries and eventually block blood flow entirely