Although many studies have shown the clinical efficacy of adding prokinetics to PPI therapy in GERD, others have shown no therapeutic benefit
Clinical Question
Thus, prokinetic agents, though effective in hypomotility conditions, are associated with multiple adverse effects
Theoretically, treatment
The initial evaluation of patients with acute upper GI bleeding involves an assessment of hemodynamic stability and resuscitation if necessary
Background: The comparative effectiveness of proton pump inhibitor versus prokinetic therapy in relieving the symptoms of patients with functional dyspepsia remains unknown
In the acute management of GERD, cisapride is superior to placebo and has the same Introduction
Prokinetic agents are drugs that enhance the activity of the smooth muscle of your gastrointestinal tract
Docusate is a surfactant laxative; it reduces tension of oil-water interface of the stool and enhances incorporation of water and fat into the stool, resulting in a softer stool
The largest prospective study was a double-blind, placebo-controlled multi-national study in FD comparing 3 doses of mosapride Current guidelines do not support the routine use of prokinetic agents for the treatment of GERD in infants or older children
Since the previous network meta-analysis assessing the efficacy of prokinetics for functional dyspepsia (FD), there have been a number of new studies and cinitapride is a new prokinetic agent for FD
Erythromycin is a potent prokinetic agent available in the market, after many countries had withdrawn cisapride from medical practice
There is a lack of evidence-based information about what drugs work best for patients with gastroparesis
In addition, antiemetics with different modes of action may be combined in patients with refractory vomiting
Vaezi et al 31 /2006: For patients who are not responding to PPI therapy, a prokinetic agent such as metoclopramide (pregnancy category B) could be added
This article summarises the current state of knowledge about the use of prokinetics and explores potential Of the 304 prescriptions analyzed, 298 (98%) included domperidone, and most commonly, it was prescribed as a fixed-dose combination (FDC) with pantoprazole (274/304, 90%)
Prokinetic agents amplify and coordinate the gastrointestinal muscular contractions to facilitate the transit of intra-luminal content