Drug interactions are reported among 30 people who take Phenytoin sodium and Theophylline
If any of these effects last or get worse, tell your Theophylline is predicted to cause hypokalaemia (potentially increasing the risk of torsade de pointes) when given with Sotalol
The CYP2C19-mediated interaction that seems to exist between clopidogrel and omeprazole or esomeprazole has been shown to be clinically important in research published since the 2006 review Interactions between oxcarbazepine and carbamazepine, phenytoin and valproic acid were investigated in a controlled study with 43 patients and showed that oxcarbazepine did not affect any of the drugs, while induction by carbamazepine and phenytoin decreased the AUC of the main metabolite, 10-OH-carbazepine, (MHD) by 40 % and 29 %, respectively
, S
Toogood, M
It is best to avoid smoking and to limit caffeine Small increases in serum concentrations can result in toxicity, particularly in patients with a level of more than 20mg/L
Identify the appropriate methods for therapeutic drug monitoring and select the course of action for phenytoin toxicity
Drug-drug interactions Several medications can substantially alter the disposition of theophylline and serve as a poten-tial source of variation in theophylline disposition {Table 2)
Manufacturer advises avoid
Subjects were given an intravenous infusion of theophylline (aminophylline), 5 mg/kg, and several blood specimens were drawn over the following 24 hr for theophylline concentration determination
New data for the more recently marketed dexlansoprazole suggest it has no impact on the pharmacokinetics of diazepam, phenytoin, theophylline and warfarin
The older AEDs are susceptible to cause induction (carbamazepine, phenobarbital, phenytoin, primidone) or inhibition (valproic acid), resulting in a decrease or increase, respectively, in the serum concentration of other AEDs, as well as other drug classes (anticoagulants, oral contraceptives, antidepressants, antipsychotics, antimicrobal drugs, Pharmacodynamics
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome): Anxiety, nervousness
If any of these effects last or get worse, tell your Side Effects
New data for the more recently marketed dexlansoprazole suggest it has no impact on the pharmacokinetics of diazepam, phenytoin, theophylline and warfarin
Includes information on severity of interaction and the level of evidence for it
Theophylline oral tablet can interact with other medications, vitamins, or herbs you may be taking
Theophylline is a medication used to treat asthma and chronic obstructive pulmonary disease as a second-line drug
Side Effects
It was originally used as a bronchodilator, but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β 2-agonists became more widely used
Propafenone
In the case of rifampicin, isoniazid or sulphinpyrazone comedication, an increase of the See the list of drugs that interact with Ciprofloxacin
Ciprofloxacin is predicted to increase the exposure to Theophylline cimetidine theophylline
What does this interaction result in?, Antiulcer agents may have interactions with the following medications and more
This chapter is concerned with how laboratory measurement of drug concentration in 7
Headache, nausea, vomiting, constipation, dizziness, feeling of spinning, drowsiness, trouble sleeping, or nervousness may occur
C
The interaction between SJW and theophylline was identified during analysis of a specific case (
3 Department of Pharmacy, University of California, San Francisco
Serum theophylline and phenytoin concentrations decrease about Theophylline decreases phenytoin 40%
1983 Mar 24;308(12):724-5
Publication types Case Reports Other macrolide antibiotics may display interactions with theophylline, which may be due in part to the ability of the various antibiotics to form complexes with isoenzymes of the cytochromes P-450
Sucralfate
It usually is taken every 6, 8, 12, or 24 hours
2 hours, with a subsequent increase in plasma theophylline clearance secondary to co The effect of age on the induction of theophylline metabolism by phenytoin was examined in healthy young and old male cigarette smokers (greater than or equal to 20 cigarettes/day) and nonsmokers
Check Phenytoin comes as an extended-release (long-acting) capsule, a chewable tablet, and a suspension (liquid) to take by mouth
Each subject received intravenous theophylline to determine baseline pharmacokinetics
Theophylline (Oral Route) Theophylline is used together with other medicines to treat the symptoms of asthma, bronchitis, emphysema, and other lung diseases
Explain the adverse effects and outline the contraindications of phenytoin therapy
Includes information on severity of interaction and the level of evidence for it
Depending on the dose and route of administration, theophylline can have a wide
The effects or lack of effects on theophylline clearance of sympathomimetics, corticosteroids, antihistamines and other antiallergy drugs, antimicrobial agents
It can also occur when
Phenytoin is extensively bound to plasma proteins and is prone to competitive
This chapter is concerned with how laboratory measurement of drug concentration
It was originally used as a bronchodilator, but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β 2-agonists became more widely used
Beta-2-blocking effect may decrease efficacy of theophylline: Propranolol: Similar to cimetidine and pharmacologic
Manufacturer advises monitor concentration and adjust dose
Abstract
Bronchodilators are medicines that relax the muscles in the bronchial tubes (air
Propafenone
In the case of rifampicin, isoniazid or sulphinpyrazone comedication, an
If your doctor does prescribe these medications together There are 829 drugs known to interact with phenytoin, along with 12 disease interactions, and 1 alcohol/food interaction
5 For example, studies have confirmed that
The effects could also be related to a blockade of the 2-hydroxylation of estradiol
Sucralfate
( 2
The extended-release capsules are usually taken one to four times a day