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Clozapine REMS Patient Information To receive treatment, a patient must be enrolled in the Clozapine REMS program by a certified doctor
CLOZARIL ® (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11- (4-methyl-1-piperazinyl)-5 H -dibenzo [ b,e]
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Subsequent dose increases can be in increments of up to 100 mg once or twice weekly
Clozapine is available under the following different brand names: Clozaril, FazaClo ODT
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This includes information on what the medication is for, how to take it, possible side effects and safety information
Check with your doctor immediately if any of the following side effects occur: dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
27 Due to its severe adverse effects profile, clozapine is only available through a restricted program under a Risk Evaluation Mitigation Strategy (REMS) called the Clozapine REMS Program
At day 31, the prescriber will be reminded that Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
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-6- Clozapine can cause a serious heart problem
metronidazole will increase the level or effect of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism
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These medicines work on the balance of chemical substances in the brain
Common side effects of clozapine include sedation, drowsiness (somnolence), dizziness, vertigo