Administration of a
Administer the first dose 30 minutes before the start of chemotherapy and subsequent doses 4 and 8 hours after the first dose
For highly emetogenic chemotherapy, a
-Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg
The first dose should be administered 30 minutes before the start of emetogenic chemotherapy, with subsequent doses 4 and 8 hours after the first dose
a Chemotherapy was high dose (100 and 120 mg/m 2; Ondansetron Injection n = 6, placebo n = 5) A single 0
Range: 4 to 24 mg by mouth, at least 30 minutes before chemotherapy
Adult patients aged less than 75 years: A single dose of intravenous ondansetron given for the prevention of CINV in adults Medscape - Nausea & vomiting dosing for Zofran, Zuplenz (ondansetron), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information
3 mg/kg/dose) or divided dosing (0
The intravenous dose must not exceed 8 mg
2): Dilution of ZOFRAN Injection is not required before administration to adult and pediatric patients
The first or single dose was administered 30 minutes prior to chemotherapy
The recommended adult intravenous dosage of ondansetron is 4 mg undiluted
5 mg) PO Aprepitant 80 mg PO daily (days 2 – 3) a if started on Day 1 The updated label will state that ondansetron can continue to be used in adults and children with chemotherapy-induced nausea and vomiting at the lower intravenous dose recommended in the drug label, a dose of 0
5-HT3 receptors are found on areas of nerves in the brain and stomach that can trigger a vomiting reflex
A second and third dose of ondansetron are sometimes given 4 hours and 8 hours after the first dose
A single dose of ondansetron 8 mg by slow intravenous injection immediately before chemotherapy has been shown to be effective in many patients
Highly emetogenic chemotherapy: 8 mg via slow IV or IM inj as a single dose immediately prior to treatment, may be followed by either a 1 mg/hour continuous IV infusion for up to 24 hours, or by 2
6 m 2) 2 mg every 12 hours for up to 5 days (dose can be started 12 hours after intravenous administration); maximum 32 mg per day
15mg/kg IV x 3 doses on day of chemo up to a maximum of 16 mg per dose Prevention of Nausea and vomiting associated with radiation therapy 8 mg IV given prior to radiation Note: oral Ondansetron is typically recommended in these instances Postoperative nausea and vomiting 4 mg IV given as a