Objectives: To evaluate the pharmacokinetics, pharmacodynamics (PD), safety, and tolerability of epidural SP-102 (10 mg dexamethasone sodium phosphate injectable gel) compared to an intravenous injection of 10 mg dexamethasone sodium phosphate, USP (IV USP)
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Taking into account the reportedly large pharmacokinetic variability and the dose dependency of dexamethasone
It is approximately three thousand times more soluble in water at 25°C than hydrocortisone
1 mg/ml
It is approximately three thousand times more soluble in water at 25°C than hydrocortisone
[PMC free article] [Google Scholar] Samtani MN, & Jusko WJ (2005b)
The aim of this study was to determine the pharmacokinetics of dexamethasone in broiler chickens
75, 1, 2, 4, 6, 8, 10, 12 and 24h after administration
Evaluation of the penetration of those agents in the site of action and their pharmacodynamic potential activity in view of the intended clinical use after cataract
The time course of plasma concentrations is presented for both healthy and arthritic rats receiving 2
Dexamethasone Sodium Phosphate Product Monograph
Dexamethasone sodium phosphate injection is generally administered initially in a dosage of 10 mg intravenously followed by four mg every six hours intramuscularly until the
Information on inner ear pharmacokinetics is limited in the literature, especially in large animals and in humans