Jul 30, 1998 · A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis
Wilhelmus KR, Gee L, Hauck WW, Herpetic Eye Disease Study: A controlled trial of topical corticosteroids for herpes simplex stromal keratitis
“At the time of HEDS, trifluridine was the most widely prescribed topical antiviral agent for treatment of HSV keratitis in the United States,” said Dr
Topical therapy with trifluridine 1% eight to nine times a day can also be prescribed, but care must be taken to ensure antiviral drops are discontinued within 10-14 days due to significant corneal toxicity
Treatment failure less with Oral acivir (50%) than placebo(68%)
HEDS I HEDS II; Objectives: Assess the efficacy of topical corticosteroids with topical trifluridine in treating simplex stromal keratitis
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Treatment failure in HEDS was 38% for patients on oral acyclovir (400 mg five times a day) and 49% of people on placebo therapy before completion of a 10-week regimen of tapering topical prednisolone phosphate and trifluridine
78 The Herpetic Eye and 75th quartiles of 50% and 139%) and for Disease Study (HEDS) designated trifluridine patients developing epithelial Oral acyclovir, 400 mg, 5 times daily for 10 weeks + topical trifluridine for 10 weeks + prednisolone phosphate 1% for 10 weeks: Herpetic Eye Disease Study Group
1056/NEJM199807303390510 The Herpetic Eye Disease Study Group: Acyclovir for the prevention of recurrent herpes simplex virus eye disease
Bruce Ostler, Natalie Kurinij, Chandler R
Information source: National Eye Institute (NEI) Intervention: Prednisolone Phosphate (Drug); Acyclovir (Drug) Phase: Phase 3
In addition, the study treated patients initially with both oral acyclovir and topical trifluridine
It was found that patients who were treated with oral acyclovir at a dose of 400 mg twice a day had a reduced risk of both epithelial and stromal keratitis by 45%
Introduction Clinical Eye and Vision Care 7 (1995) 151-154 News and views section The herpetic eye disease study Timothy Harkins VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA simplex virus (HSV) keratitis is a serious corneal problem
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oral prophylaxis of antivirals was established with the HEDS Each patient was placed on a therapeutic dose of oral acyclovir
AbstractThe Herpetic Eye Disease Study (HEDS) was a randomized, double-masked, placebo-controlled, clinical trial to determine the efficacy of topical corticost
placebo in patients already on topical corticosteroids and trifluridine showed no improvement in et al:Herpetic eye disease study
The HEDS trial had 5 main study arms spread across 2 studies (HEDS1 and HEDS2)